FINAL SCIENTIFIC PROGRAMME

Saturday 19^th

10:00 – 16:00 Buses from Madrid Airport to Salamanca.
17:00 – 19:00 Arrival, Registration and Posters fixing.
19:00 – 19:10 Opening Ceremony

Auditorium.
Chairmen: Gianfrancesco Goracci (ESN President, Perugia, Italy) and Juan P. Bolaños (Chair of the Organizing Committee, ESN Secretary, Salamanca, Spain).

19:10 – 20:00 Opening Lecture (Portland Press Session)

Chairman: Jackeline de Belleroche (Chair of the International Programme Committee, London, UK).
Mark P. Mattson (National Institute on Aging Intramural Research Program, Baltimore, USA).
The Fine Line Between Neuronal Plasticity and Disease

20:00 – 22:00 Welcome Cocktail (place to be announced)

Sunday 20^th

09:00 – 11:00: Symposium S1: ROLE OF GLIA IN NEUROPROTECTION AND NEURODEGENERATION.
Journal of Neurochemistry 50th Anniversary Session

Auditorium
Organizers and chairmen: Ralf Dringen (University of Bremen, Germany), Phillip Beart (University of Melbourne, Australia) and Christian Giaume (College de France, Paris, France)

Ralf Dringen (University of Bremen, Germany)
Peroxide detoxification and iron-mediated toxicity in astrocytes

Christiane Richter-Landsberg (University of Oldenburg, Germany)
Stress responses in oligodendrocytes: implications for neurodegenerative diseases

Niels Danbolt (University of Oslo, Norway)
Glutamate transport as a key function of astrocytes

Philip Beart (University of Melbourne, Australia)
Preconditioning, hypoxic inducible factor and cytoprotection

Christian Naus (University of British Columbia, Vancouver, Canada)
Control of cell proliferation by glial connexins

11:00 – 11:30 Coffee break

11:30 – 13:00: Parallel Workshop Sessions W1 and W2:
W1: MICROGLIA - AIDING AND ABETTING NEURODEGENERATION?

Auditorium
Organizer and chairman: Jennifer Pocock (Institute of Neurology, London, UK)

Jennifer Pocock (Institute of Neurology, University College London, UK)
Microglial activation in neurodegenerative and neuroinflammatory disease: control by neurotransmiiter receptors.

Monica J Carson (University of California Riverside, USA)
Fine tuning microglial activation toward neuroprotection or cytodestruction: the role of two new receptor families.

Gennadij Raivich (University College London, UK)
Inflammation and the neurodegenerative process in perinatal brain damage.

Paula Agostinho (University of Coimbra, Portugal)
Microglial activation induced by amyloid beta and prion peptides: role in neurodegeneration.

W2: NEUROPSYCHIATRIC DISORDERS, MODELS AND THERAPEUTIC APPROACHES

Lecture Theatre
Organizer and chairman: Elisabeth Bock (Panum Institute, University of Copenhagen, Denmark)

Alexander Zharkovsky (University of Tartu, Estonia)
Animal models of dysfunctional brain plasticity and their relation to depressive state.

Gal Richter-Levin (The Weizmann Institute, Rehovot, Israel)
Formation of emotional and traumatic memories: role of neuronal cell adhesion molecules.

Carmen Sandi (Ecole Polytechnique Federale de Lausanne, Switzerland)
Stress and Psychopathology: Animal models and Therapeutic Approaches.

Vladimir Berezin (Panum Institute, University of Copenhagen, Denmark)
Impairment of glutamatergic neurons in the prefrontal cortex by means of phencyclidin: therapeutic approaches.

13:00 – 14:30 Lunch

14:30 – 15:00: Poster Session 1: Glial and Neuronal Metabolism, Mitochondria and Neurotransmitters.

15:00 – 15:30: Poster Session 2: Oxygen and Nitrogen-derived Free Radicals in Neuroprotection and Neurodegeneration.

15:30 – 16:30: Young Investigator Awards Session (Neuhoff-Fricke Foundation Session.

Auditorium
Chairmen: Ferdinand Hucho (ESN Council Member, Berlin, Germany) and Gianfrancesco Goracci (ESN President, Perugia, Italy).

José L. Madrigal (Instituto de Farmacología y Toxicología, CSIC-UCM, Madrid, Spain)
Neuroprotective actions of noradrenaline: potencial role of MCP-1.

Inga Markiewicz (NeuroRepair Dep, Med Res Inst, Pol Acad Sci, Warsaw, Poland)
Glial cells activated by LPS and TMT attenuate neurogenesis from human umbilical cord blood derived neural stem cells (HUCB-NSC).

16:30 – 17:00 Coffee break

17:00 – 18:30: Parallel Workshop Sessions W3 and W4:
W3: NEUROPROTECTIVE STRATEGIES FOR INHERITED AND ACQUIRED MITOCHONDRIAL DISEASE

Auditorium
Organizer and chariman: Simon Heales (Institute of Neurology, London, UK).

John Land (National Hospital for Neurology and Neurosurgery, London, UK)
Inherited mitochondrial disease, pathogenesis and therapeutic approaches

Simon Heales (Institute of Neurology, London, UK)
Oxidative stress, mitochondrial dysfunction, neurodegeneration/ neuroprotection

Vera Adam-Vizi (University of Budapest, Hungary)
Oxygen radical generation and brain mitochondrial dysfunction

Joao Laranjinha (University Coimbra, Portugal)
Monitoring brain nitric oxide formation and respiration

Gavin Davey (Trinity College, Dublín, Ireland)
Energy tresholds and mitochondrial dysfunction

W4: PROPERTIES OF HEAT SHOCK PROTEINS: CAN THEY BE HARNESSED FOR TREATMENT OF NEURODEGENERATIVE CONDITIONS?

Lecture Theatre
Organizer and chairman: J de Belleroche (Imperial College London, UK)

Jackie de Belleroche (Imperial College London, UK)
Neuroprotective properties of HSP27 in epilepsy, nerve injury and ALS.

Andreas Wyttenbach (University of Southampton, UK)
Neuroprotection by heat shock proteins during polyglutamine aggregation and toxicity.

Cinzia Dello Russo (University of Rome, Italy)
Neuroprotective mechanisms activated by HSP90 inhibitors.

Vittorio Calabrese (University of Catania, Italy)
Redox regulation of HSPs expression in Aging and Neurodegenrative Disorders: Role of Vitagenes.

[18:30 – 20:00: ESN Council Business Meeting] (Classroom)

Free evening

Monday 21^st

09:00 – 11:00: Symposium S2: NEW HOPE FOR STROKE: THE BRAIN PLASTICITY.

Ferrer Group Session

Auditorium
Organizers and chairmen: Jose Castillo (University of Santiago de Compostela, Spain) and M. Angeles Moro (Complutense University Madrid, Spain).

Pedro Ramos-Cabrer (Max Plank Institute Colonia, Germany)
Functional MRI, and poststroke recovery.

Zaal Kokaia (University of Lund, Sweden)
Brain plasticity in recovery from stroke: a cellular point of view.

Barbro B Johansson (University of Lund, Sweden)
Recovery from stroke: From neuronal to brain plasticity.

Ignacio Lizasoain (Complutense University Madrid, Spain)
Pharmacological modulation of plasticity in the human brain.

11:00 – 11:30 Coffee break

11:30 – 13:00 Parallel Workshop Sessions W5 and W6:
W5: NEURAL KCNQ (KV7) POTASSIUM CHANNELS: ROLE IN NEUROLOGICAL DISEASE AND TARGETS FOR THERAPEUTICS.

Auditorium
Organizer and chairman: David A. Brown (London, UK)
Chair's introductory remarks: Overview of neural KCNQ channels: composition, function, regulation, pharmacology and disease.

Alvaro Villarroel (University of the Basque Country, Bilbao, Spain)
Trafficking and membrane insertion of functional KCNQ channels

Maurizio Taglialatela (University of Molise, Italy)
Presynaptic role of KCNQ channels.

Gayle Passmore (University College London)
Role of KCNQ channels in nociception and implications for treatment of neuropathic pain.

Mami Noda (University of Kyushu, Japan)
KCNQ channels in microglial cells and implications for inflammation and neuroprotection.

W6: INHERITED PERIPHERAL NEUROPATHIES AND SCHWANN CELL BIOLOGY.

Lecture Theatre
Organizer and chairman: Peter J. Brophy (Edinburgh, UK)

Kleopas A. Kleopa (The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus)
Gap junctions in myelinating cells.

Dies Meijer (Department of Cell Biology & Genetics, Erasmus University Medical Center, Rotterdam, Holland)
Role of Lgi proteins in nerve development and function.

Laura Feltri (San Raffaele Scientific Institute, DIBIT, Milan, Italy)
Beta1 integrin activate Rac1 to promote radial axonal sorting: role in laminin-deficient neuropathies.

Francesc Palau (Institute of Biomedicine, Spanish Council for Scientific Research (CSIC), Valencia, Spain)
Mitochondrial involvement in the pathogenesis of Charcot-Marie-Tooth disease.

Larry Wrabetz  (San Raffaele Scientific Institute, DIBIT, Milan, Italy)
Endoplasmic Reticulum Stress and Pathogenesis of CMT1B Neuropathy.

Peter Brophy  (Centre for Neuroscience Research, Edinburgh University, UK)
Cajal band and demyelinating neuropathy.

13:00 – 14:30 Lunch

14:30 – 15:00: Poster Session 3: Hypoxia, Ischemia and Stroke: Mechanisms of Neurotoxicity and Novel Neuroprotective Strategies.

15:00 – 15:30: Poster Session 4: Cell Signalling Mechanisms in Neuropro tection, Neurogenesis and Neurorepair.

15:30 – 16:15 The Herman Bachelard Memorial Lecture

(Sigma-Aldrich Química Session)

Auditorium
Chairmen: John B. Clark (London, UK) and Vera Adam-Vizi (Budapest, Hungary)

Carlos Vicario-Abejón (Instituto Cajal, CSIC, Madrid, Spain)
Neurogenesis in the embryonic and adult brain: strategies for neurorepair.

16:15 – 17: 30: ESN General Meeting (Auditorium)

17:30– 18:00: Wines.

18:00– 19:30: Guided visit to Salamanca.

19:30– 20:30: Concert.

Tuesday 22^nd

09:00 – 10:30: Symposium S3: ROLE OF THE ENDOCANNABINOID SYSTEM IN NEUROGENESIS AND NEUROREPAIR.

(Caja Duero Session)

Auditorium
Organizer and chairman: Manuel Guzman (Complutense University Madrid, Spain).
Chair's introductory remarks: The endocannabinoid signaling system.

Ismael Galve-Roperh (Complutense University Madrid, Spain)
Expression and function of the endocannabinoid system in neural progenitors

Tibor Harkany (Karolinska Institutet Stockholm, Sweeden)
The role of endocannabinoid signaling in axon guidance and synapse specification during corticogenesis

David A. Greenberg (Buck Institute for Age Research, Novato, USA)
The therapeutic potential of cannabinoids in brain injury and neurodegenerative diseases

10:30 – 11:00 Coffee break

11:00 – 12:00 SHORT COMMUNICATIONS OF SELECTED POSTERS.
Auditorium
Chairmen: Dusan Dobrota (ESN Treasurer, Martin, Slovakia) and Victor Tsetlin (Moscow, Russia).

K. Szydlowska (Nencki Institute of Experimental Biology, Warsaw, Poland)
Mechanism of glutamate-induced astrocyte death – a proapoptic role of ERK signaling
(Poster PS1-12)

M. Rattray (King’s College London, London, UK)
Development of epitope-tagged EAAT2 for analysis of glutamate transporter subunit interactions and regulation
(Poster PS1-16)

H. L. A. Vieira (Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal)
Carbon monoxide as a new protector against neuronal apoptosis
(Poster PS2-10)

M. Morawski (Paul Flechsig Institute of Brain Research, Leipzig, Germany)
Iron compartmentalisation in the rat brain: Do perineuronal net-ensheathed neurons play a special role?
(Poster PS2-17)

H. Cimarosti (University of Bristol, Bristol, UK)
Protein SUMOylation: Investigation in in vivo models of brain ischemia
(Poster PS3-01)

T. Sobrino (Clinical Neuroscience Research Laboratory, Santiago de Compostela, Spain)
High serum levels of VEGF, SDF-1a and active MMP-9 are associated with proliferation of endothelial progenitor cells in human ischemic stroke
(Poster PS3-12)

12:00 – 13:00: The Porcellati lecture

(Porcellati Foundation Session)

Auditorium
Chairman: Gianfrancesco Goracci (Perugia, Italy)

Hee-Yong Kim (National Institutes of Health, Bethesda, USA)
Neurotrophic Effect of Docosahexaenoic Acid: Involvement of Phosphatidylserine.

13:00 – 14:15 Lunch

14:30 – 15:00 Poster Session 5: Neurodegenerative Diseases: Mechanisms, Animal Models and Neuroprotective Strategies.

15:00 – 16:00: SHORT COMMUNICATIONS OF SELECTED POSTERS
Auditorium
Chairmen: Katarzyna Nalecz (Warsaw, Poland) and Michal Linial (Jerusalem, Israel)
Speakers to be selected by the International Programme Committee.

A. M. Dolga (University of Groningen, Groningen, The Netherlands)
A novel lovastatin-mediated neuroprotective signaling mechanism
(Poster PS4-04)

J. Cuende (University Hospital of Salamanca, Salamanca, Spain)
APC-Cdh1-mediated Skp2 degradation is essential for retinoic acid-induced cell cycle arrest and neuroblastoma differentiation
(Poster PS4-20)

M. Vignes (University Montpellier 2, Montpellier, France)
Metabotropic glutamate mGlu5 receptor-dependent forms of hippocampal synaptic plasticity triggered by low-frequency stimulation
(Poster PS4-24)

D. L. Pountney (Griffith University, Gold Coast, Australia)
Formation of spherical and annular a-Synuclein oligomers is enhanced by calcium-binding and oxidation
(Poster PS5-10)

M. Stepanichev (Institute of Higher Nervous Activity and Neurophysiology, Moscow, Russia)
Ab(25-35) has opposite effects on cell proliferation in different neurogenic zones of rat brain
(Poster PS5-23)

A. Pujol (Institut d’Investigació Biomèdica de Bellvitge, Barcelona, Spain)
Neurodegeneration in X-ALD: dangerous liaisons between mitochondria and peroxisomes?
(Poster P5-27)

16:00 – 16:30 Coffee break

16:30 – 18:00: Symposium S4: MECHANISMS OF NEUROPROTECTION AGAINST AMYLOID BETA PEPTIDE-INDUCED TOXICITY

(Hucoa-Erloss Session)

Auditorium
Organizer and chairman: Rafael Alonso (University of La Laguna, Spain)

Chris Peers (University of Leeds, UK)
Roles for amyloid beta peptides in Ca2+ homeostasis and survival of neurones and astrocytes

Lucía Núñez (University of Valladolid, Spain)
Salicilate and NSAIDs protect against Aß-induced neurotoxicity by preventing mitochondrial overload.

Raquel Marín (Institute of Biomedical Technologies, University of La Laguna, Spain)
A plethora of factors interacting at the plasma membrane are involved in the prevention of amyloid-ß-induced neurotoxicity.

18:00 – 18:30 Closing remarks.
Jackeline de Belleroche (Chair of the International Programme Committee, London, UK) and Juan P. Bolaños (Chair of the Local Organizing Committee, Salamanca, Spain).

20:30 – 23:30 Gala dinner NH Puerta de la Catedral. Reservations required.

Wednesday 23^rd

Departure (Buses to Madrid Airport).